Single-Blinded Study Highlighting the Differences between the Small Intestines of Neonatal and Weaned Piglets

The gut is one of the body’s major immune structures, and mucosa, which contains intestinal epithelium subepithelial cells, primary site for eliciting local responses to foreign antigens. Intestinal system development in pigs a transitional period during birth weaning. This study compares morphological immunological differences small intestine neonatal weaned piglets potentially prevent infectious diseases piglets. Histological analyses piglet intestines showed increased crypt depth, higher IEL count, larger ileal Peyer’s patches compared with those neonates. Additionally, villi were longer than piglets, claudin-3 protein expression was significantly numbers CD3+ T, goblet, secretory cells also No significant observed IgA-positive cell number jejunum mRNA most pattern recognition receptors genes duodenum piglets; however, opposite true ileum. levels IL-1? TNF-? jejunal mucosa There fewer CD3+, CD4+, CD8+ T from peripheral blood-mononuclear Our provides insights regarding different mechanisms within 0- 21-day-old Studies on additional developmental stages how affect response pathogens remain warranted.